Journal Publications

2022

Wang G, Lam WKJ, Ling L, Ma ML, Ramakrishnan S, Chan DCT, Lee WS, Cheng SH, Chan RWY, Yu SCY, Tse IOL, Wong WT, Jiang P, Chiu RWK, Chan KCA, Lo YMD. Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis. Clinical Chemistry 2022 Dec 28; hvac197, https://doi.org/10.1093/clinchem/hvac197

 

Stephanie C Y Yu, Jiaen Deng, Rong Qiao, Suk Hang Cheng, Wenlei Peng, So Ling Lau, L.Y. Lois Choy, Tak Y Leung, John Wong, Vincent Wai-Sun Wong, 

Grace L H Wong, Peiyong Jiang, Rossa W K Chiu, K C Allen Chan, Y M Dennis Lo. Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma. Clinical Chemistry 2022 Nov 02; hvac180, https://doi.org/10.1093/clinchem/hvac180

 

Qing Zhou, Guannan Kang, Peiyong Jiang, Rong Qiao, W. K. Jacky Lam, Stephanie C. Y. Yu, Mary-Jane L. Ma, Lu Ji, Suk Hang Cheng, Wanxia Gai, Wenlei Peng, Huiman Shang, Rebecca W. Y. Chan, Stephen L. Chan, Grace L. H. Wong, Linda T. Hiraki, Stefano Volpi, Vincent W. S. Wong, John Wong, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo.  Epigenetic analysis of cell-free DNA by fragmentomic profiling. PNAS 2022 Oct 26;119 (44) e2209852119.

 

Stephanie C Y Yu, K C Allen Chan. What is the Importance of Analyzing Tumor Tissues and Blood Cells in the Study of Circulating Tumor-Derived DNA?. Clinical Chemistry 2022 Oct 17; hvac168, https://doi.org/10.1093/clinchem/hvac168

 

Chen M, Chan RWY, Cheung PPH, Ni M, Wong DKL, Zhou Z, Ma ML, Huang L, Xu X, Lee WS, Wang G, Lui KO, Lam WKJ, Teoh JYC, Ng CF, Jiang P, Chan KCA, Chiu RWK, Lo YMD. Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models. PLOS Genetics 2022 Jul 6;18(7):e1010262. doi: 10.1371/journal.pgen.1010262. eCollection 2022 Jul.

 

Choy LYL, Peng W, Jiang P, Cheng SH, Yu SCY, Shang H,Tse OYO, Wong J, Wong VWS, Wong GLH, Lam WKJ, Chan SL, Chiu RWK, Chan KCA, Lo YMD. Single-molecule Sequencing Enables Long Cell-free DNA Detection and Direct Methylation Analysis for Cancer Patients. Clinical Chemistry 2022 May 19:  https://doi.org/10.1093/clinchem/hvac086

 

C. T. Chan, W. K. J. Lam, E. P. Hui, B. B. Y. Ma, C. M. L. Chan, V. C. T. Lee, S. H. Cheng, W. Gai, P. Jiang, K. C. W. Wong, F. Mo, B. Zee, A. D. King, Q. T. Le, A. T. C. Chan, K. C. A. Chan & Y. M. D. Lo. Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein-Barr virus DNA in post-treatment plasma. Annals of Oncology 2022 Apr 28. doi: https://doi.org/10.1016/j.annonc.2022.04.068

 

Sin ST, Deng J, Ji L, Yukawa M, Chan RW, Volpi S, Vaglio A, Fenaroli P, Bocca P, Cheng SH, Wong DK, Lui KO, Jiang P, Chan KCA, Chiu RW, Lo YMD. Effects of nucleases on cell-free extrachromosomal circular DNA. JCI Insight 2022 Apr 22;7(8):e156070.doi:10.1172/jci.insight.156070.

 

Ding SC, Lo YMD. Cell-Free DNA Fragmentomics in Liquid Biopsy. Diagnostics(Basel) 2022 Apr 13;12(4):978. doi: 10.3390/diagnostics12040978. PMID: 35454026; PMCID: PMC9027801.

 

Jiang P, Lo YMD. Enhanced cancer detection from cell-free DNA. Nature Biotechnology 2022 Apr;40(4):473-474. doi: 10.1038/s41587-021-01207-9. PMID:35361997.

 

Xie T, Wang G, Ding SC, Lee WS, Cheng SH, Chan RWY, Zhou Z, Ma ML, Han DSC, Teoh JYC, Lam WKJ, Jiang P, Chiu RWK, Chan KCA, Lo YMD. High-resolution analysis for urinary DNA jagged ends. NPJ Genomic Medicine 2022 Feb 23;7(1):14. doi: 10.1038/s41525-022-00285-1.

 

2021

SCY Yu,  P Jiang, W Peng, SH Cheng, YTT Cheung,  OYO Tse, H Shang, LC Poon, TY Leung, KCA Chan,  RWK Chiu, YMD Lo.  Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.  PNAS  2021 December 14;118 (50) e2114937118.  

 

JSL Vong, L Ji, MMS Heung, SH Cheng, J Wong, PBS Lai, VWS Wong, SL Chan, HLY Chan, P Jiang, KCA Chan, RWK Chiu, YMD Lo.  Single Cell and Plasma RNA Sequencing for RNA Liquid Biopsy for Hepatocellular Carcinoma.  Clinical Chemistry 2021; 67(11): 1492 – 1502.

 

YMD Lo.  Noninvasive prenatal testing: Advancing through a virtuous circle of science, technology and clinical applications.  Prenatal Diagnosis 2021; 41(10): 1190-1192.

 

RWK Chiu, YMD Lo.  Cell-free fetal DNA coming in all sizes and shapes.  Prenatal Diagnosis 2021; 41(10): 1193-1201.

 

DSC Han, YMD Lo.  The Nexus of cfDNA and Nuclease Biology. Trends in Genetics 2021; 37(8): 758-770.