Journal Publications

2024

W Gai, G Wang, WKJ Lam, LYP Yuen, P Jiang, SCY Yu, TY Leung, SL Lau, YMD Lo, KCA Chan. Universal Targeted Haplotyping by Droplet Digital PCR Sequencing and Its Applications in Noninvasive Prenatal Testing and Pharmacogenetics Analysis. Clinical Chemistry 2024 Jun 14; hvae076, https://doi.org/10.1093/clinchem/hvae076


SCY Yu, YMD Lo. Biological Insights from Cell-Free DNA Methylome Analysis in Preeclampsia. Clinical Chemistry 2024 Mar 07; hvae020, https://doi.org/10.1093/clinchem/hvae020

 

H Che, P Jiang, LLY Choy, SH Cheng, W Peng, RWY Chan, J Liu, Q Zhou, JWK Lam, SCY Yu, SL Lau, TY Leung, J Wong, VWS Wong, GLH Wong, SL Chan, AKC Chan, YMD Lo. Genomic origin, fragmentomics, and transcriptional correlation of long cell-free DNA molecules in human plasma. Genome Research 2024 Feb 26:gr.278556.123. https://doi.org/10.1101/gr.278556.123

AD King, QYH Ai, WKJ Lam, IOL Tse, TY So, LM Wong, JYM Tsang, HS Leung, BCY Zee, EP Hui, BBY Ma, AC Vlantis, AC Van Hasselt, ATC Chan, JKS Woo, KCA Chan. Early detection of nasopharyngeal carcinoma: performance of a short contrast-free screening MRI. JNCI: Journal of the National Cancer Institute, djad260, https://doi.org/10.1093/jnci/djad260

 

2023

WKJ Lam, G Kang, WSW Wong. Circulating tumour DNA for detection of minimal residual disease in head and neck squamous cell carcinoma: A new hope. Ann Oncol. 2023 Dec;34(12):1080-1081. https://doi.org/10.1016/j.annonc.2023.10.693

 

AK Mattox, C Douville, Y Wong, M Popoli, J Ptak, N Silliman, L Dobbyn, J Schaefer, S Lu, AH Pearlman, JD Cohen, J Tie, P Gibbs, K Lahouel, C Bettegowda, RH Hruban, C Tomasetti, P Jiang, KCA Chan, YMD Lo, N Papadopoulos, KW Kinzler, B Vogelstein. The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer. Cancer Discovery 2023 Oct 5;13(10):2166-2179. https://doi.org/10.1158/2159-8290.CD-21-1252


PJ Lou, WKJ Lam, WL Hsu, RM Pfeiffer, KJ Yu, CML Chan, VCT Lee, TC Chen, SD Terng, YA Tsou, YS Leu, LJ Liao, YL Chang, YC Chien, CP Wang, CY Lin, CH Hua, JC Lee, TL Yang, CH Hsiao, MS Wu, MH Tsai, HC Cheng, A Hildesheim, CJ Chen, KCA Chan, Z Liu. Performance and Operational Feasibility of Epstein-Barr Virus-Based Screening for Detection of Nasopharyngeal Carcinoma: Direct Comparison of Two Alternative Approaches. J Clin Oncol. 2023 Sep 10;41(26):4257-4266. doi: 10.1200/JCO.22.01979

 

W Gai, SCY Yu, WTC Chan, W Peng, SL Lau, TY Leung, P Jiang, KCA Chan, YMD Lo. Droplet digital PCR is a cost-effective method for analyzing long cell-free DNA in maternal plasma: Application in preeclampsia. Prenatal Diagnosis 2023 Sep 01. https://doi.org/10.1002/pd.6432

 

SCY Yu, LYL Choy, YMD Lo. ‘Longing’ for the Next Generation of Liquid Biopsy: The Diagnostic Potential of Long Cell-Free DNA in Oncology and Prenatal Testing. Molecular Diagnosis & Therapy 2023 Jul 20. https://doi.org/10.1007/s40291-023-00661-2

 

KCA Chan, WKJ Lam, A King, VS Lin, PPH Lee, BCY Zee, SL Chan, IOL Tse, AFC Tsang, MZJ Li, P Jiang, QYH Ai, DMC Poon, EP Hui, BBY Ma, AC Van Hasselt, ATC Chan, JKS Woo, YMD Lo.  Plasma EpsteinBarr Virus DNA and Risk of Future Nasopharyngeal Cancer. NEJM Evid 2023; 2(7). https://doi.org/10.1056/EVIDoa2200309

 

Z Zhou, MJL Ma, RWY Chan, WKJ Lam, W Peng, W Gai, X Hu, SC Ding, L Ji, Q Zhou, PPH Cheung, SCY Yu, JYC Teoh, CC Szeto, J Wong, VWS Wong, GLH Wong, SL Chan, EP Hui, BBY Ma, ATC Chan, RWK Chiu, KCA Chan, YMD Lo, P Jiang. Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs. PNAS 2023 Apr 19; 120 (17) e2220982120. https://doi.org/10.1073/pnas.2220982120

 

G Wang, WKJ Lam, L Ling, MJL Ma, S Ramakrishnan, DCT Chan, WS Lee, SH Cheng, RWY Chan, SCY Yu, IOL Tse, WT Wong, P Jiang, RWK Chiu, KCA Chan, YMD Lo. Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis. Clinical Chemistry 2023 Feb 1; 69(2): 189-201. https://doi.org/10.1093/clinchem/hvac197

 

SCY Yu, J Deng, R Qiao, SK Cheng, W Peng, SL Lau, LYL Choy, TY Leung, J Wong, VWS Wong, GLH Wong, P Jiang, RWK Chiu, KCA Chan, YMD Lo. Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma. Clinical Chemistry 2023 Feb 1;69(2):168-179. https://doi.org/10.1093/clinchem/hvac180

 

WKJ Lam, AD King, JA Miller, Z Liu, KJ Yu, MLK Chua, BBY Ma, MY Chen, BA Pinksy, PJ Lou, JKS Woo, WL Hsu, J Simon, DL Doolan, T Waterboer, EP Hui, H Li, RK Tsang, KCW Wong, JP Goh, AC Vlantis, QY Ai, LM Wong, V Abdullah, JC Lin, CJ Chem, RM Pfeiffer, QT Le, AWM Lee, M Ji, S Cao, J Ma, ATC Chan, KC Chan, A Hildesheim. Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions. JNCI: Journal of the National Cancer Institute 2023 Feb 01; 115(4) 355-364. https://doi.org/10.1093/jnci/djad012

 

2022

Q Zhou, G Kang, P Jiang, R Qiao, WKJ Lam, SCY Yu, MJL Ma, L Ji, SK Cheng, W Gai, W Peng, H Shang, RWY Chan, SL Chan, GLH Wong, LT Hiraki, S Volpi, VWS Wong, JWong, RWK Chiu, KCA Chan, YMD Lo. Epigenetic analysis of cell-free DNA by fragmentomic profiling. PNAS 2022 Oct 26;119 (44) e2209852119. https://doi.org/10.1073/pnas.2209852119

 

SCY Yu, KCA Chan. What is the Importance of Analyzing Tumor Tissues and Blood Cells in the Study of Circulating Tumor-Derived DNA?. Clinical Chemistry 2022 ; 68(12): 1481-1483. https://doi.org/10.1093/clinchem/hvac168

 

M Chen, RWY Chan, PPH Cheung, M Ni, DKL Wong, Z Zhou, ML Ma, L Huang, X Xu, WS Lee, G Wang, KO KO, WKJ Lam, JYC Teoh, CF Ng, P Jiang, KCA Chan, RWK Chiu, YMD Lo. Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models. PLOS Genetics 22022 Jul 6;18(7):e1010262. https://doi.org/10.1371/journal.pgen.1010262

 

LYL Choy, W Peng, P Jiang, SH Cheng, SCY Yu, H Shang, OYO Tse, J Wong, VWS Wong, GLH Wong, WKJ Lam, SL Chan, RWK Chiu, KCA Chan,  YMD Lo.  Single-molecule Sequencing Enables Long Cell-free DNA Detection and Direct Methylation Analysis for Cancer Patients. Clinical Chemistry 2022; 68(9): 1151-1163. https://doi.org/10.1093/clinchem/hvac086

 

DCT Chan, WKJ Lam, EP Hui, BBY Ma, CML Chan, VCT Lee, SH Cheng, W Gai, P Jiang, KCW Wong, F Mo, B Zee, AD King, QT Le, ATC Chan, KCA Chan & YMD Lo.  Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein-Barr virus DNA in post-treatment plasma. Annals of Oncology 2022; 33(8): 794-803.  https://doi.org/10.1016/j.annonc.2022.04.068

 

ST Sin, J Deng, L Ji, M Yukawa, RW Chan, S Volpi, A Vaglio, P Fenaroli, P Bocca, SH Cheng, DK Wong, KO Lui, P Jiang, KCA Chan, RW KChiu, YMD Lo. JCI Insight 2022 Apr 22;7(8):e156070.  10.1172/jci.insight.156070

 

SC Ding, YMD Lo. Cell-Free DNA Fragmentomics in Liquid Biopsy. Diagnostics 2022 Apr 13;12(4):978. https://doi.org/10.3390/diagnostics12040978

 

P Jiang, YMD Lo. Enhanced cancer detection from cell-free DNA. Nature Biotechnology 2022 Apr;40(4):473-474. https://doi.org/10.1038/s41587-021-01207-9

 

WKJ Lam, YMD Lo. Plasma Epstein-Barr virus DNA analysis for personalised management of nasopharyngeal carcinoma—current opportunities and challenges. Ann Nasopharynx Cancer 2022;6:4. https://doi.org/10.21037/anpc-21-11

 

T Xie, G Wang, SC Ding, WS Lee, SH Cheng, RWY Chan, Z Zhou, ML Ma, DSC Han, JYC Teoh, WKJ Lam, P Jiang, RWK Chiu, KCA Chan, YMD Lo. High-resolution analysis for urinary DNA jagged ends. NPJ Genomic Medicine 2022 Feb 23;7(1):14. https://doi.org/10.1038/s41525-022-00285-1

 

2021

SCY Yu,  P Jiang, W Peng, SH Cheng, YTT Cheung,  OYO Tse, H Shang, LC Poon, TY Leung, KCA Chan,  RWK Chiu, YMD Lo.  Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.  PNAS  2021 December 14;118 (50) e2114937118.  

 

JSL Vong, L Ji, MMS Heung, SH Cheng, J Wong, PBS Lai, VWS Wong, SL Chan, HLY Chan, P Jiang, KCA Chan, RWK Chiu, YMD Lo.  Single Cell and Plasma RNA Sequencing for RNA Liquid Biopsy for Hepatocellular Carcinoma.  Clinical Chemistry 2021; 67(11): 1492 – 1502.

 

YMD Lo.  Noninvasive prenatal testing: Advancing through a virtuous circle of science, technology and clinical applications.  Prenatal Diagnosis 2021; 41(10): 1190-1192.

 

RWK Chiu, YMD Lo.  Cell-free fetal DNA coming in all sizes and shapes.  Prenatal Diagnosis 2021; 41(10): 1193-1201.

 

DSC Han, YMD Lo.  The Nexus of cfDNA and Nuclease Biology. Trends in Genetics 2021; 37(8): 758-770.  

Book Chapters

2023

SCY Yu, JCH Tsang, YMD Lo. Noninvasive prenatal testing for genetic diseases. Human Reproductive and Prenatal Genetics. PCK Leung, J Qiao. 2 ed. 789-821 pgs. Elsevier, 2023.04.21