Journal Publications

2023

W Gai, SCY Yu, WTC Chan, W Peng, SL Lau, TY Leung, P Jiang, KCA Chan, YMD Lo. Droplet digital PCR is a cost-effective method for analyzing long cell-free DNA in maternal plasma: Application in preeclampsia. Prenatal Diagnosis 2023 Sep 01. https://doi.org/10.1002/pd.6432

 

SCY Yu, LYL Choy, YMD Lo. ‘Longing’ for the Next Generation of Liquid Biopsy: The Diagnostic Potential of Long Cell-Free DNA in Oncology and Prenatal Testing. Molecular Diagnosis & Therapy 2023 Jul 20. https://doi.org/10.1007/s40291-023-00661-2

 

KCA Chan, WKJ Lam, A King, VS Lin, PPH Lee, BCY Zee, SL Chan, IOL Tse, AFC Tsang, MZJ Li, P Jiang, QYH Ai, DMC Poon, EP Hui, BBY Ma, AC Van Hasselt, ATC Chan, JKS Woo, YMD Lo.  Plasma Epstein–Barr Virus DNA and Risk of Future Nasopharyngeal Cancer. NEJM Evid 2023; 2(7) DOI: 10.1056/EVIDoa2200309

 

Z Zhou, MJL Ma, RWY Chan, WKJ Lam, W Peng, W Gai, X Hu, SC Ding, L Ji, Q Zhou, PPH Cheung, SCY Yu, JYC Teoh, CC Szeto, J Wong, VWS Wong, GLH Wong, SL Chan, EP Hui, BBY Ma, ATC Chan, RWK Chiu, KCA Chan, YMD Lo, P Jiang. Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs. PNAS 2023 Apr 19; 120 (17) e2220982120. https://doi.org/10.1073/pnas.2220982120

 

G Wang, WKJ Lam, L Ling, MJL Ma, S Ramakrishnan, DCT Chan, WS Lee, SH Cheng, RWY Chan, SCY Yu, IOL Tse, WT Wong, P Jiang, RWK Chiu, KCA Chan, YMD Lo. Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis. Clinical Chemistry 2023 Feb 1; 69(2): 189-201. https://doi.org/10.1093/clinchem/hvac197

 

SCY Yu, J Deng, R Qiao, SK Cheng, W Peng, SL Lau, LYL Choy, TY Leung, J Wong, VWS Wong, GLH Wong, P Jiang, RWK Chiu, KCA Chan, YMD Lo. Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma. Clinical Chemistry 2023 Feb 1;69(2):168-179. https://doi.org/10.1093/clinchem/hvac180.

 

WKJ Lam, AD King, JA Miller, Z Liu, KJ Yu, MLK Chua, BBY Ma, MY Chen, BA Pinksy, PJ Lou, JKS Woo, WL Hsu, J Simon, DL Doolan, T Waterboer, EP Hui, H Li, RK Tsang, KCW Wong, JP Goh, AC Vlantis, QY Ai, LM Wong, V Abdullah, JC Lin, CJ Chem, RM Pfeiffer, QT Le, AWM Lee, M Ji, S Cao, J Ma, ATC Chan, KC Chan, A Hildesheim. Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions. JNCI: Journal of the National Cancer Institute 2023 Feb 01; 115(4) 355-364. https://doi.org/10.1093/jnci/djad012

 

2022

Q Zhou, G Kang, P Jiang, R Qiao, WKJ Lam, SCY Yu, MJL Ma, L Ji, SK Cheng, W Gai, W Peng, H Shang, RWY Chan, SL Chan, GLH Wong, LT Hiraki, S Volpi, VWS Wong, JWong, RWK Chiu, KCA Chan, YMD Lo. Epigenetic analysis of cell-free DNA by fragmentomic profiling. PNAS 2022 Oct 26;119 (44) e2209852119. https://doi.org/10.1073/pnas.2209852119

 

SCY Yu, KCA Chan. What is the Importance of Analyzing Tumor Tissues and Blood Cells in the Study of Circulating Tumor-Derived DNA?. Clinical Chemistry 2022 ; 68(12): 1481-1483. https://doi.org/10.1093/clinchem/hvac168

 

M Chen, RWY Chan, PPH Cheung, M Ni, DKL Wong, Z Zhou, ML Ma, L Huang, X Xu, WS Lee, G Wang, KO KO, WKJ Lam, JYC Teoh, CF Ng, P Jiang, KCA Chan, RWK Chiu, YMD Lo. Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models. PLOS Genetics 22022 Jul 6;18(7):e1010262. https://doi.org/10.1371/journal.pgen.1010262

 

LYL Choy, W Peng, P Jiang, SH Cheng, SCY Yu, H Shang, OYO Tse, J Wong, VWS Wong, GLH Wong, WKJ Lam, SL Chan, RWK Chiu, KCA Chan,  YMD Lo.  Single-molecule Sequencing Enables Long Cell-free DNA Detection and Direct Methylation Analysis for Cancer Patients. Clinical Chemistry 2022; 68(9): 1151-1163. https://doi.org/10.1093/clinchem/hvac086

 

DCT Chan, WKJ Lam, EP Hui, BBY Ma, CML Chan, VCT Lee, SH Cheng, W Gai, P Jiang, KCW Wong, F Mo, B Zee, AD King, QT Le, ATC Chan, KCA Chan & YMD Lo.  Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein-Barr virus DNA in post-treatment plasma. Annals of Oncology 2022; 33(8): 794-803.  https://doi.org/10.1016/j.annonc.2022.04.068

 

ST Sin, J Deng, L Ji, M Yukawa, RW Chan, S Volpi, A Vaglio, P Fenaroli, P Bocca, SH Cheng, DK Wong, KO Lui, P Jiang, KCA Chan, RW KChiu, YMD Lo. JCI Insight 2022 Apr 22;7(8):e156070.  10.1172/jci.insight.156070

 

SC Ding, YMD Lo. Cell-Free DNA Fragmentomics in Liquid Biopsy. Diagnostics 2022 Apr 13;12(4):978. https://doi.org/10.3390/diagnostics12040978

 

P Jiang, YMD Lo. Enhanced cancer detection from cell-free DNA. Nature Biotechnology 2022 Apr;40(4):473-474. https://doi.org/10.1038/s41587-021-01207-9

 

T Xie, G Wang, SC Ding, WS Lee, SH Cheng, RWY Chan, Z Zhou, ML Ma, DSC Han, JYC Teoh, WKJ Lam, P Jiang, RWK Chiu, KCA Chan, YMD Lo. High-resolution analysis for urinary DNA jagged ends. NPJ Genomic Medicine 2022 Feb 23;7(1):14. https://doi.org/10.1038/s41525-022-00285-1

 

2021

SCY Yu,  P Jiang, W Peng, SH Cheng, YTT Cheung,  OYO Tse, H Shang, LC Poon, TY Leung, KCA Chan,  RWK Chiu, YMD Lo.  Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.  PNAS  2021 December 14;118 (50) e2114937118.  

 

JSL Vong, L Ji, MMS Heung, SH Cheng, J Wong, PBS Lai, VWS Wong, SL Chan, HLY Chan, P Jiang, KCA Chan, RWK Chiu, YMD Lo.  Single Cell and Plasma RNA Sequencing for RNA Liquid Biopsy for Hepatocellular Carcinoma.  Clinical Chemistry 2021; 67(11): 1492 – 1502.

 

YMD Lo.  Noninvasive prenatal testing: Advancing through a virtuous circle of science, technology and clinical applications.  Prenatal Diagnosis 2021; 41(10): 1190-1192.

 

RWK Chiu, YMD Lo.  Cell-free fetal DNA coming in all sizes and shapes.  Prenatal Diagnosis 2021; 41(10): 1193-1201.

 

DSC Han, YMD Lo.  The Nexus of cfDNA and Nuclease Biology. Trends in Genetics 2021; 37(8): 758-770.